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• Juvenile rheumatoid arthritis diagnosis criteria trial#

Unlike adult rheumatoid arthritis, which is ongoing (chronic) and lasts a lifetime, children often outgrow. JIA is arthritis that affects one or more joints for at least 6 weeks in a child age 16 or younger. Explore symptoms, inheritance, genetics of this. Arthritis causes joint swelling (inflammation) and joint stiffness. Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis ) that first appears before the age of 16.

Worsening in any 2/6 CRV by > or = 40% without concomitant improvement of more than one of the remaining CRV by > or = 30% appears to be the most suitable preliminary flare definition. Juvenile idiopathic arthritis (JIA) is a form of arthritis in children. Two other superior flare definitions were (1) worsening in 3/6 CRV by > or = 30% and (2) any worsening of the Childhood Health Assessment Questionnaire, worsening of erythrocyte sedimentation rate by > or = 30% and worsening of the active joint count by > or = 10%.ĬRV are useful for defining flare in JRA. Of the possible flare definitions tested with acceptable statistical properties, the one that seemed to be the most useful was worsening in any 2/6 CRV by > or = 40% without improvement in more than 1 of the remaining CRV by > or = 30%. Candidate flare definitions were assessed by receiver-operator characteristic (ROC) curve properties and other statistics for diagnostic tests.

The criterion standard of flare was treatment with placebo.

Juvenile rheumatoid arthritis diagnosis criteria trial#

To develop preliminary criteria for defining disease flare in patients with polyarticular-course juvenile rheumatoid arthritis (JRA).ĭata from a randomized clinical trial of etanercept in JRA (51 patients) and the 6 core response variables (CRV) for JRA were used to derive flare definitions.